Prognostic impact of micromegakaryocytes in primary myelodysplastic syndromes.

Saumell S, Fernández-Serrano M, Mesa A, López-Cadenas F, Arenillas L, Alfonso A, Montoro MJ, Molero A, Leoz P, Riego V, Gallur L, Salamero O, Navarrete M, Tazón-Vega B, Ortega M, Reig Ò, Roué G, Calvo X, Prosper F, Díez-Campelo M, Valcárcel D. Leuk Lymphoma. 2021 Dec 31:1-9. doi: 10.1080/10428194.2021.2018581. Online ahead of print. PMID: 34969346

Monocyte subset distribution in myeloproliferative and myelodysplastic/myeloproliferative neoplasms with monocytosis.

Sorigue, M., Arenillas, L., Xicoy, B., Andrade-Campos, M., Navarro, J. T., Ferrer, A., Zamora, L., & Calvo, X. (2022). Leukemia Research, 112. https://doi.org/10.1016/j.leukres.2021.106771

Prognostic impact of micromegakaryocytes in primary myelodysplastic syndromes.

Saumell, S., Fernández-Serrano, M., Mesa, A., López-Cadenas, F., Arenillas, L., Alfonso, A., Montoro, M. J., Molero, A., Leoz, P., Riego, V., Gallur, L., Salamero, O., Navarrete, M., Tazón-Vega, B., Ortega, M., Reig, Ò., Roué, G., Calvo, X., Prosper, F., … Valcárcel, D. (2021). Leukemia & Lymphoma, 1–9. https://doi.org/10.1080/10428194.2021.2018581

Coexistence of JAK2V617F mutation and isolated del(5q) in a patient with thrombocytosis.

Marcé, S., Ruiz-Xivillé, N., & Arenillas, L. (2021). Medicina Clinica, 156(12), 625–627. https://doi.org/10.1016/j.medcli.2020.04.065

Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification—an approach to classification of patients with t-MDS.

Kuendgen, A., Nomdedeu, M., Tuechler, H., Garcia-Manero, G., Komrokji, R. S., Sekeres, M. A., Della Porta, M. G., Cazzola, M., DeZern, A. E., Roboz, G. J., Steensma, D. P., Van de Loosdrecht, A. A., Schlenk, R. F., Grau, J., Calvo, X., Blum, S., Pereira, A., Valent, P., Costa, D., … Sanz, G. (2021). Leukemia, 35(3), 835–849. https://doi.org/10.1038/s41375-020-0917-7

Molecular and cytogenetic characterization of myelodysplastic syndromes in cell-free DNA.

Garcia-Gisbert, N., Garcia-Avila, S., Merchan, B., Salido, M., Fernández-Rodríguez, C., Gibert, J., Camacho, L., Fernández-Ibarrondo, L., Lafuente, M., Longarón, R., Espinet, B., Velez, P., Pujol, R. M., Andrade-Campos, M., Arenillas, L., Salar, A., Calvo, X., Besses, C., & Bellosillo, B. (2022). Blood Advances. https://doi.org/10.1182/bloodadvances.2021006565

Oligomonocytic and overt chronic myelomonocytic leukemia show similar clinical, genomic, and immunophenotypic features.

Calvo, X., Garcia-Gisbert, N., Parraga, I., Gibert, J., Florensa, L., Andrade-Campos, M., Merchan, B., Garcia-Avila, S., Montesdeoca, S., Fernández-Rodríguez, C., Salido, M., Puiggros, A., Espinet, B., Colomo, L., Roman-Bravo, D., Bellosillo, B., Ferrer, A., & Arenillas, L. (2020). Blood Advances, 4(20), 5285–5296. https://doi.org/10.1182/BLOODADVANCES.2020002206

Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival.

Cabezón, M., Malinverni, R., Bargay, J., Xicoy, B., Marcé, S., Garrido, A., Tormo, M., Arenillas, L., Coll, R., Borras, J., Jiménez, M. J., Hoyos, M., Valcárcel, D., Escoda, L., Vall-Llovera, F., Garcia, A., Font, L. L., Rámila, E., Buschbeck, M., & Zamora, L. (2021). Clinical Epigenetics, 13(1). https://doi.org/10.1186/S13148-021-01002-Y

Generation of two heterozygous GATA2 CRISPR/Cas9-edited iPSC lines, R398W and R396Q, for modeling GATA2 deficiency.

Julio Castaño, Damia Romero-Moya, Yvonne Richaud-Patin, Alessandra Giorgetti. Stem Cell Res 2021:102445. doi: 10.1016/j.scr.2021.102445

Clinical, biological, and prognostic implications of SF3B1 co-occurrence mutations in very low/low- and intermediate-risk MDS patients.

Kamila Janusz*; Marta Martín Izquierdo*; Félix López Cadenas; Fernando Ramos; Jesús María Hernández Sánchez; Eva Lumbreras; Cristina Robledo; Javier Sánchez del Real; Juan Carlos Caballero; Rosa Collado; Teresa Bernal; Carme Pedro; Andrés Insunza; Raquel de Paz; Blanca Xicoy; Eduardo Salido; Joaquín Sánchez García; Sandra Santos Mínguez; Cristina Miguel García; Ana María Simón Muñoz; Mercedes Sánchez Barba; Jesús María Hernández Rivas; María Abáigar*; María Díez Campelo*.
Ann Hematol. 2021 Aug;100(8):1995-2004. doi: 10.1007/s00277-020-04360-4. Epub 2021 Jan 6

Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia.

Marta Martín-Izquierdo; María Abáigar; Jesús M Hernández-Sánchez; David Tamborero; Félix López-Cadenas; Fernando Ramos; Eva Lumbreras; Andrés Madinaveitia-Ochoa; Marta Megido; Jorge Labrador; Javier Sánchez-Real; Carmen Olivier; Julio Dávila; Carlos Aguilar; Juan N Rodríguez; Guillermo Martín-Núñez; Sandra Santos-Mínguez; Cristina Miguel-García; Rocío Benito; María Díez-Campelo; Jesús M Hernández-Rivas. Haematologica. 2021 Aug 1;106(8):2215-2223. doi: 10.3324/haematol.2020.248807.

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

Oster, HS (Oster, Howard S.) 1, 2Crouch, S (Crouch, Simon) 3Smith, A (Smith, Alexandra) 3Yu, G (Yu, Ge) 3Abu Shrkihe, B (Abu Shrkihe, Bander) 1Baruch, S (Baruch, Shoham) 4Kolomansky, A (Kolomansky, Albert) 1, 4Ben-Ezra, J (Ben-Ezra, Jonathan) 2, 5Naor, S (Naor, Shachar) 5Fenaux, P (Fenaux, Pierre) 6, 7Symeonidis, A (Symeonidis, Argiris) 8Stauder, R (Stauder, Reinhard) 9Cermak, J (Cermak, Jaroslav) 10Sanz, G (Sanz, Guillermo) 11Hellstrom-Lindberg, E (Hellstrom-Lindberg, Eva) 12Malcovati, L (Malcovati, Luca) 13Langemeijer, S (Langemeijer, Saskia) 14Germing, U (Germing, Ulrich) 15Holm, MS (Holm, Mette Skov) 16Madry, K (Madry, Krzysztof) 17Guerci-Bresler, A (Guerci-Bresler, Agnes) 18Culligan, D (Culligan, Dominic) 19Sanhes, L (Sanhes, Laurence) 20Mills, J (Mills, Juliet) 21, 22Kotsianidis, I (Kotsianidis, Ioannis) 23van Marrewijk, C (van Marrewijk, Corine) 14Bowen, D (Bowen, David) 24de Witte, T (de Witte, Theo) 25Mittelman, M (Mittelman, Moshe

Blood Adv. 2021 Aug 24;5(16):3066-3075. doi: 10.1182/bloodadvances.2020004055.

Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic Features in Myelodysplastic Syndromes

Bersanelli M, Travaglino E, Meggendorfer M, Matteuzzi T, Sala C, Mosca E, Chiereghin C, Di Nanni N, Gnocchi M, Zampini M, Rossi M, Maggioni G, Termanini A, Angelucci E, Bernardi M, Borin L, Bruno B, Bonifazi F, Santini V, Bacigalupo A, Voso MT, Oliva E, Riva M, Ubezio M, Morabito L, Campagna A, Saitta C, Savevski V, Giampieri E, Remondini D, Passamonti F, Ciceri F, Bolli N, Rambaldi A, Kern W, Kordasti S, Sole F, Palomo L, Sanz G, Santoro A, Platzbecker U, Fenaux P, Milanesi L, Haferlach T, Castellani G, Della Porta MG.

J Clin Oncol. 2021 Apr 10;39(11):1223-1233. doi: 10.1200/JCO.20.01659. Epub 2021 Feb 4.

Outcomes of patients with chronic myelomonocytic leukaemia treated with non-curative therapies: a retrospective cohort study

isa Pleyer, Michael Leisch, Alexandra Kourakli, Eric Padron, Jaroslaw Pawel Maciejewski, Blanca Xicoy Cirici, Jennifer Kaivers, Johanna Ungerstedt, Sonja Heibl, Peristera Patiou, Anthony Michael Hunter, Elvira Mora, Klaus Geissler, Maria Dimou, Maria-José Jimenez Lorenzo, Thomas Melchardt, Alexander Egle, Athina-Nora Viniou, Bhumika Jayantibhai Patel, Montserrat Arnan, Peter Valent, Christoforos Roubakis, Teresa Bernal del Castillo, Athanasios Galanopoulos, Marisa Calabuig Muñoz, Nicolas Bonadies, Antonio Medina de Almeida, Jaroslav Cermak, Andrés Jerez, Maria Julia Montoro, Albert Cortés, Alejandro Avendaño Pita, Bernardo Lopez Andrade, Eva Hellstroem-Lindberg, Ulrich Germing, Mikkael Aaron Sekeres, Alan Francis List, Argiris Symeonidis, Guillermo Francisco Sanz, Julian Larcher-Senn, Richard Greil, DOI: 10.1016/S2352-3026(20)30374-4 Lancet Haematol

Cryopreservation of Allogeneic Hematopoietic Progenitor Cells in The Current SARS-Cov-2 Pandemic: Experience of A Single Centre

Moreno, D.; Navarro, L.; Solves, P.; Plume, G.; Gomez, I.; Picazo, M. D.; Pous, A.; Penalver, M. I.; Arbona, C.; Sanz, G.; Carpio, N.. Bone Marrow Transplantation ; 56(SUPPL 1):97-98, 2021.

Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E.

Nat Med. 2021 May;27(5):927. doi: 10.1038/s41591-021-01367-w.

Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.

Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E.

Nat Med. 2021 Mar;27(3):562. doi: 10.1038/s41591-021-01253-5.

Omidubicel Versus Standard Myeloablative Umbilical Cord Blood Transplantation: Results of a Phase III Randomized Study

Horwitz ME, Stiff PJ, Cutler CS, Brunstein CG, Hanna R, Maziarz RT, Rezvani AR, Karras NA, McGuirk JP, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WY, Koh LP, Keating AK, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz GF. Blood. 2021 Jun 22:blood.2021011719. doi: 10.1182/blood.2021011719. Epub ahead of print. PMID: 34157093.

Adoptive transfer of ex vivo expanded SARS-CoV-2-specific cytotoxic lymphocytes: A viable strategy for COVID-19 immunosuppressed patients?

Guerreiro M, Aguilar-Gallardo C, Montoro J, Francés-Gómez C, Latorre V, Luna I, Planelles D, Carrasco MP, Gómez MD, González-Barberá EM, Aguado C, Sempere A, Solves P, Gómez-Seguí I, Balaguer-Rosello A, Louro A, Perla A, Larrea L, Sanz J, Arbona C, de la Rubia J, Geller R, Sanz MÁ, Sanz G, Luis Piñana J. Transpl Infect Dis. 2021 Aug;23(4):e13602. doi: 10.1111/tid.13602. Epub 2021 Mar 31.

Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation

Coco de Koning, Weiyang Tao, Amelia Lacna, Karin van Veghel, Mitchell E. Horwitz, Guillermo Sanz, Madan H. Jagasia, John E. Wagner, Patrick J. Stiff, Rabi Hanna, Daniela Cilloni, David Valcárcel, Tony Peled, Einat Galamidi Cohen, Uri Goshen, Aridaman Pandit, Caroline A. Lindemans, Jaap Jan Boelens & Stefan Nierkens

Bone Marrow Transplantation. DOI: 10.1038/s41409-021-01417-4

Single-Run Next-Generation Sequencing (NGS) Assay for the Simultaneous Detection of Both Gene Mutations and Large Chromosomal Abnormalities in Patients with Myelodysplastic Syndromes (MDS) and Related Myeloid Neoplasms.

Liquori A, Lesende I, Palomo L, Avetisyan G, Ibáñez M, González-Romero E, Boluda-Navarro M, Morote-Faubel M, Garcia-Ruiz C, Martinez-Valiente C, Santiago-Balsera M, Gomez-Seguí I, Sanjuan-Pla A, Sanz MA, Sanz G, Solé F, Such E, Cervera J. A Cancers (Basel). 2021 Apr 18;13(8):1947. PMID: 33919541. IF: 6.126.

Analysis of Intratumoral Heterogeneity in Myelodysplastic Syndromes with Isolated del(5q) Using a Single Cell Approach.

Acha P*, Palomo L*, Fuster-Tormo F, Xicoy B, Mallo M, Manzanares A, Grau J, Marcé S, Granada I, Rodríguez-Luaces M, Diez-Campelo M, Zamora L, Solé F.

Cancers (Basel). 2021 Feb 17;13(4):841. PMID: 33671317. IF: 6.639.

Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations.

Martín I, Villamón E, Abellán R, Calasanz MJ, Irigoyen A, Sanz G, Such E, Mora E, Gutiérrez M, Collado R, García-Serra R, Vara M, Blanco ML, Oiartzabal I, Álvarez S, Bernal T, Granada I, Xicoy B, Jerez A, Calabuig M, Diez R, Gil Á, Díez-Campelo M, Solano C, Tormo M; Spanish Group of Myelodysplastic Syndromes (GESMD). Br J Haematol. 2021 Aug;194(4):708-717.