64th ASH Annual Meeting and Exposition. New Orleans, Lousiana (USA). 7-10 diciembre, 2022

ERCC6L2 in Early-Onset Adult Myelodysplastic Syndrome without Pre-Existing Disorder.

Salvador Carrillo-Tornel1*, Tzu Hua Chen-Liang, MD PhD2*, Ana Yeguas Bermejo3*, Helena Pomares, PhD4*, Alessandro Liquori, PhD5*, Teresa González6*, Teresa Bernal del Castillo7*, Marta Santiago8*, Félix López Cadenas, MD9*, Bernardo López Andrade, MD10*, Raul Teruel Montoya, PhD11*, Esperanza Such, PhD12*, Francisca Maria Hernandez, DM13*, Blanca Xicoy, MD14*, Montserrat Arnan Sangerman, PhD15*, Francesc Solé, PhD16, Jose Cervera, MD, PhD17*, Maria Diez-Campelo, MD18* and Andres Jerez, MD, PhD19*.

Multiplex CRISPR/Cas9 gene editing in human stem cells to model clonal competition in GATA2 Deficiency

Damia Romero-Moya, Oskar Marin-Bejar, Maximiliano Distefano, Joan Pera, Julio Castaño, Jessica Gonzales, Lili Kotmayer, Csaba Bödör, Albert Català, Marcin Wlordaski, Anna Bigas, Alessandra Giorgetti.

Myelodysplastic Syndromes Presenting With Isolated Thrombocytopenia: A Less Aggressive Form Of Presentation And With Better Prognosis.

Ms. Flores-Morán , L. Arenillas , A. Ferrer , F. Lopez-Cadenas , S. Garcia-Avila , C. Fernandez , A. Salar And X. Calvo. Hospital Del Mar, Barcelona, Spain

Characterization of Transcriptional Alterations Leading to Aberrant Myeloid Differentiation in Myelodysplastic Syndromes

Aintzane Diaz-Mazkiaran, MSc, Jesús De la Fuente, MSc, Guillermo Serrano, BSc, Paula Garcia-Olloqui, PhD, Nerea Berastegui, Marina Ainciburu, MSc, Ana Alfonso Pierola, MD, Amaia Vilas-Zornoza, PhD, Patxi San Martin-Uriz, PhD, Jose Maria Lamo De Espinosa, Mikel San Julián, Pamela Acha, Francesc Solé, PhD, Tamara Jimenez, Félix López Cadenas, MD, Maria Diez-Campelo, MD, Antonieta Molero, MD, Maria Julia Montoro, MD, PhD, David Valcarcel, MD, PhD, Teresa Ezponda, Mikel Hernáez, PhD, Felipe Prosper, MD.

Subclonal Kit D816v Mutations Are Prevalent In Chronic Myelomonocytic Leukemia And Correlate With Distinct Phenotypic Features.

Anthony Hunter, Hannah Newman, Eric Solary, Klaus Geissler, Laura Palomo, Francesc Sole, Valeria Santini, Timothy Graubert, Swapna Thota, Elizabeth Griffiths, Lisa Pleyer, Felicitas Thol, Rafael Bejar, Tracy George, Eric Padron.

Title: Inferring Aberrant Expression Dynamics Across Early Myeloid Differentiation To Discover Potential Therapeutic Targets In Myelodysplastic Syndromes.

Aintzane Díaz-Mazkiaran, Jesús De La Fuente, Guillermo Serrano, Paula Garcia-Olloqui, Nerea Berastegui, Marina Ainciburu, Ana Alfonso, Amaia Vilas-Zornoza, Patxi San Martin, Jose Lamo De Espinosa, Mikel San Julián, Pamela Acha, Francesc Solé, Tamara Jimenez, Félix López, María Díez-Campelo, Antonieta Molero, María Julia Montoro, David Valcarcel, Teresa Ezponda, Mikel Hernaez, Felipe Prósper

Incidence, Clinical Associations, And Co-Mutation Patterns Of Uba1 Mutations In Mds.

Maria Sirenko, Elsa Bernard, Ph.D., David Beck, M.D., Ph.D., Maria Creignou, M.D., Dylan Domenico, B.S., Andrea Farina, Ph.D., Juan E. Arango Ossa, M.S., Olivier Kosmider, M.D., Ph.D., Robert P. Hasserjian, M.D., Martin Jädersten, M.D., Ph.D., Ulrich Germing, M.D., Guillermo Sanz, M.D., Ph.D., Arjan A. Van De Loosdrecht, M.D., Ph.D., Matilde Y. Follo, Ph.D., Felicitas Thol, M.D., Lurdes Zamora, Ph.D., Ronald F. Pinheiro, Ph.D., Andrea Pellagatti, Ph.D., Harold K. Elias, M.D., Detlef Haase, M.D., Ph.D., Christina Ganster, Ph.D., Lionel Ades, M.D., Ph.D., Magnus Tobiasson, M.D., Ph.D., Laura Palomo, Ph.D., Matteo Giovanni Della Porta, M.D., Kety Huberman, B.S., Pierre Fenaux, M.D., Ph.D., Monika Belickova, Ph.D., Michael R. Savona, M.D., Virginia M. Klimek, M.D., Fabio P. S. Santos, M.D., Ph.D., Jacqueline Boultwood, Ph.D., Ioannis Kotsianidis, M.D., Ph.D., Valeria Santini, M.D., Francesc Solé, Ph.D., Uwe Platzbecker, M.D., Michael Heuser, M.D., Peter Valent, M.D., Carlo Finelli, M.D., Maria Teresa Voso, M.D., Lee-Yung Shih, M.S., Seishi Ogawa, M.D., Ph.D., Michaela Fontenay, M.D., Ph.D., Joop H. Jansen, Ph.D., José Cervera, M.D., Ph.D., Benjamin L. Ebert, M.D., Ph.D., Rafael Bejar, M.D., Ph.D., Peter L. Greenberg, M.D., Norbert Gattermann, M.D., Luca Malcovati, M.D., Mario Cazzola, M.D., Eva Hellström-Lindberg, M.D., Ph.D., And Elli Papaemmanuil, Ph.D.

Clinical Implications Of P53 Dysfunction In Patients With Myelodysplastic Syndromes.

Elena Riva, Matteo Zampini, Alberto Termanini, Lorenzo Dall’olio, Alessandra Merlotti, Austin Kulasekararaj, Michela Calvi, Clara Di Vito, Daoud Rahal, Arturo Bonometti, Giorgio Croci, Emanuela Boveri, Umberto Gianelli, Maurilio Ponzoni, Antonio Russo, Benedetta Tinterri, Francesca Re, Elisabetta Sauta, Elena Saba, Erica Travaglino, Marta Ubezio, Alessia Campagna, Luca Lanino, Giulia Maggioni, Cristina A Tentori, Chiara Milanesi, Nicla Manes, Saverio D’amico, Francesca Ficara, Laura Crisafulli, Domenico Mavilio, Enrico Lugli, Armando Santoro, Maria Diez-Campelo, Guillermo Sanz, Francesc Solé, Uwe Platzbecker, Valeria Santini, Shahram Kordasti, Pierre Fenaux, Torsten Haferlach, Daniel Remondini, Gastone Castellani, And Matteo G Della Porta, On Behalf Of Genomed4all Consortium (Genomics And Personalized Medicine For All Through Artificial Intelligence In Haematological Diseases – Www.Genomed4all.Eu).

Wt1 Mrna Upregulation In Acute Myeloid Leukemia (Aml) In Complete Molecular Remission (Mcr): Understanding The Limitations And Potential Advantages Of Wt1 As A Measurable Residual Disease (Mrd) Target.

Albert Esquirol, Yolanda Guillen, Elena Bussaglia, Vanesa Criado, Maite Carricondo, Pamela Acha, Manel Esteller, Jorge Sierra, Francesc Solé, Anna Bigas, Josep F. Nomdedéu.

Tp53 Allelic State In Myelodysplastic Syndromes With 5q Deletion.

Maria Julia Montoro, Laura Palomo, Pablo Vidal, Francesc Solé, Esperanza Such, Francisco Fuster-Tormo, Teresa González, Margarita Ortega, Félix López, Sara García-Avila, Nieves García-Gisbert, Eugenia Rivero, María Díez-Campelo, Andrés Jerez, Francesc Bosch, David Valcárcel

Inter-Laboratory Comparison Study Of Optical Genome Mapping Analysis For Cytogenomic Characterization Of Hematological Malignancies: A Spanish Multi-Center Study.

Anna Puiggros, Mar Mallo, Marta Salido, Ana Gómez-García, Rocío García-Serra, Adela Cisneros, Celia González, Gayane Avestisyan, María Rodríguez-Rivera, Alvaro Díaz, Isabel Granada, Esperanza Such, Eulàlia Genescà, Rosa Collado, Manuel Ramírez-Orellana, Francesc Solé, Blanca Espinet.

Long-Term Evolution of Somatic Mutations in Patients with Del(5q) MDS Early Treated with Lenalidomide in the Sintra-Rev Clinical Trial: Safe and Effecitive Approach?

Sofía M Toribio Castelló, Felix Lopez-Cadenas, MD, Claude Preudhomme,PharmD, PhD, Angela Villaverde Ramiro, Laurène Fenwarth, MD, PhD,Eva Lumbreras, Teresa González, Mónica Del Rey, Blanca Xicoy,MD, Aline Renneville, MD, PhD, Joaquín Sánchez-Garcia, MD,Rosa Coll, MD, Bohrane Slama, José Ángel Hernández-Rivas, MD, PhD, Sylvain Thepot, Teresa Bernal, MD, PhD, Agnès Guerci-Bresler, MD,PhD, Katharina Götze, Jesús María Hernández-Rivas, MD, PhD, Pierre Fenaux, MD, PhD, Consuelo Del Cañizo, MD, PhD and Maria Diez-Campelo, MD, PhD

TP53 Allelic state in del 5Qmds

Maria Julia Montoro, Laura Palomo, Pablo Vidal, Francesc Solé, Esperanza Such, Francisco Fuster-Tormo, Teresa González, Margarita Ortega, Félix López, Sara García-Avila, Nieves García-Gisbert, Eugenia Rivero, María Díez-Campelo, Andrés Jerez, Francesc Bosch, David Valcárcel

EHA 2022 Congress (Hybrid). Viena (Austria). 9-12 junio, 2022

Factors Driving Treatment Decision In Patients With Intermediate-Risk Myelodysplastic Syndrome (Mds): A Retrospective Analysis From The Grupo Español De Síndromes Mielodisplásicos Spanish Mds Registry

María Díez Campelo, David Valcárcel , Jordi Curto , Antonieta Guliana Molero Yordi , Guillermo Sanz Santillana, Andres Jerez, Teresa Cedena, Montserrat Arnan, Marina Diaz BEya, Mar Tormo, L. Hernandez Donoso, Sasse, Emma Colicino, Silvia

Treatment Patterns and Overall Survival in Patients with Intermediate-Risk Myelodysplastic Syndrome (MDS): A Retrospective Analysis in the Grupo Español de Síndromes Mielodisplásicos (GESMD) Spanish MDS Registry

María Díez-Campelo,1-3 Luis E. Benlloch,2 Emma Sasse,4 David Wormser,4 Leyla Hernandez Donoso,4 Silvia Colicino,4 Teresa Bernal,5 Antonieta Molero Yordi,6 Mar Tormo,2,7,8 Montserrat Arnan Sangerman,9 Guillermo Sanz,3,10 Marina Díaz-Beyá,11 María Teresa Cedena Romero,12 Andrés Jerez,13 Brayan Merchán,14 David Valcárcel Ferreiras2,5

ESH 8th Translational Research Conference: MYELODYSPLASTIC SYNDROMES. Virtual. 7-10 abril, 2022

ALLOGENEIC STEM CELL TRANSPLANTATION IN CHRONIC MYELOMONOCYTIC LEUKEMIA. A SINGLE CENTER EXPERIENCE AND DISSECTION OF MUTATIONAL PROFILE

Alejandro Avendaño Pita, Marta Martín-Izquierdo, Ana Yeguas Bermejo, Mónica del Rey, Sofía Toribio Castelló, Sandra Muntión, Tamara Jimenez Solas, Eva Lumbreras Gonzalez, María Cortés Rodríguez, Sara Marcos Asensio, Ana-Africa Martin, M Dolores Caballero, Mónica Cabrero Calvo, Teresa González, Jesús M Hernández-Rivas, María Díez-Campelo